Neutralization of IL-17 by active vaccination inhibits IL-23-dependent autoimmune myocarditis
نویسندگان
چکیده
منابع مشابه
IL-23-dependent IL-17 drives Th1-cell responses following Mycobacterium bovis BCG vaccination.
The generation of effective type 1 T helper (Th1)-cell responses is required for immunity against intracellular bacteria. However, some intracellular bacteria require interleukin (IL)-17 to drive Th1-cell immunity and subsequent protective host immunity. Here, in a model of Mycobacterium bovis Bacille Calmette-Guerin (BCG) vaccination in mice, we demonstrate that the dependence on IL-17 to driv...
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متن کاملAlteration of IL-17 related protein expressions in experimental autoimmune myocarditis and inhibition of IL-17 by IL-10-Ig fusion gene transfer.
BACKGROUND T-helper (Th)1/Th2 cytokine balance plays an important role in the pathogenesis of myocarditis. Recently, some studies indicate that interleukin (IL)-17, known as a T cell (Th17)-derived proinflammatory cytokine, is the major mediator of tissue inflammation in inflammatory and autoimmune diseases. Experimental autoimmune myocarditis (EAM) is a T cell-mediated autoimmune disease; howe...
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ژورنال
عنوان ژورنال: European Journal of Immunology
سال: 2006
ISSN: 0014-2980,1521-4141
DOI: 10.1002/eji.200636484